Introduction to PreGender Test (for Gender Planning Before Pregnancy)

It has been known for a long time that men have approximately 50-50% mixed suspension of X- and Y-chromosome-bearing sperm which actually ‘determine' the gender. Nobody seriously thought of womens' role in this. We welcome you to an exciting concept that the female reproductive system also contributes to the gender of a baby. Our hypothesis is that ovulation creates two types of hormonal environments in the uterus, one environment is more suitable for the conception of a baby boy, and the other more suitable to a baby girl. Please see example below.

 In summary, we made the following new discoveries based on which we launched our preconception testing program:

1. Women have an equal role in baby's gender formation. Whereas sperms 'determine' the gender, fetal propagation appears to be 'influenced' by the hormonal environment of the uterus at the time of conception.
   
   
2. Ovulation creates two types of hormonal environments in the uterus probably due to difference in the ratio of sex hormones of the follicular fluid.
   
   
3. These environments alternate in consecutive mentrual cycles. In one cycle, the Testosterone/Estrogen ratio may be more than 1.0 and in other <1.0
   
   
4. The environment with T/E ratio >1.0 favors conception of boys and that <1.0 favors girls.
   
   
5. The process of conception "locks" the existing environment, till the baby is miscarried or born. That means that after conception, you will not alternate and whatever environment was there at the time of conception, will remain till the baby is miscarried or born. This goes parallel to the fact that you miss your periods after conception till the baby is miscarried or born. This is the most striking observation which medical professionals must note.
   
   
6. We developed and perfected clear methods to identify these environments by testing mid-cycle urine sample.
   
   
7. Proved and established all of the above findings to conclude that gender specific conception is possible if one conceives in appropriate environment

We had initially though that the success rate of preconception program would be near 80% but now we see that it is coming close to 94%. The method is 100% natural, non-invasive & without any medication. Customers do not have to see us or travel to our facilities because hormonal environments can be detected by testing urine samples sent by mail. If a company promises you a boy or girl, without testing anything, it is probably a scam and is not going to work. (US & Intl patents pending).

We were the first to initiate this work in 1984 and sent for publication to Medical Hypotheses in 1988 simply to make a record of it. Between 2005 and 2008 there have been several publications in the medical field to substantiate our vision. Following are some of them with relevant abstracts:

1) M. Perret, "Relationship between urinary estrogen levels before conception and sex ratio at birth in a primate, the gray mouse lemur," 2005: Human Reproduction, vol 20 (6), (1504-1510). In primates, including humans, bias of sex ratio at birth has been reported to depend on maternal condition at conception. It was hypothesized to be related to changes in hormonal state at ovulation. Direction of sex ratio was significantly dependent on Estradiol levels during follicular phase. Reduced estradiol levels prior to estrus led to male biased litters. This suggests a sex selective sperm selection at conception time. http://humrep.oxfordjournals.org/cgi/content/abstract/20/6/1504

2)  Grant V. J. et al., "Sex of Bovine Embryos may be Related to Mother’s Preovulatory Follicular Testosterone," Jan. 2008, Biology of Reproduction. A higher level of follicular testosterone is associated with a greater likelihood of conceiving a male. In a study (n=171) follicular testosterone level were significantly higher for subsequently male embryos. This study observed that a bovine egg that developed in follicular fluid with high concentration of testosterone were significantly more likely to be fertilized by Y-chromosome bearing spermatozoa. It was further observed that although the gender of the offspring in mammals is commonly viewed as a matter of chance (depending on whether an X- or a Y-chromosome-bearing sperm reaches the egg first), evolutionary biologists have shown that offspring sex ratios are often significantly related to maternal dominance, a characteristic which has been shown to be linked to testosterone in female mammals, including humans. Hence we hypothesized that variations in female testosterone might be related to reproductive mechanisms associated with sex determination, with higher levels of follicular testosterone being associated with a greater likelihood of conceiving a male. Please click on the following link to read more about this study, which supports our hypothesis: http://www.biolreprod.org/cgi/rapidpdf/biolreprod.107.066050v1.pdf

3) Greenspan F.S. et al., "Basic and Clinical Endocrinology." 4th edition. London: Prentice Hall; 1994: 426-431. This text claims that human female follicular fluid has 10,000 to 30,000 times more testosterone than that in blood.

Further explanation and details about our hypothesis

Existing Knowledge

We test two mid-cycle urine sample in order to determine the uterine biochemical environment at the time of ovulation. We hypothesize that there are two different uterine environments, one more conducive to male conception, and the other more conducive to female conception. This leads us to the following four possible scenarios:

Our new concept

Thus, if one can know the type of hormonal environment in a particular menstrual cycle, the chances of conceiving a specific gender are higher. In simple words, if a couple wishes to plan for a baby girl, they should try conception in a month when the uterine environment is more conducive to a girl conception

EXAMPLE: Suppose a couple is trying to conceive a girl. We will initially test two mid-cycle urine samples to identify the pattern of the hormonal environment. If cycle 1 is found to be suitable for conception of a girl and cycle 2 for conception of a boy, then this woman’s cycles are determined to be gender-specific alternating cycles. Cycles 3, 5, 7, 9 and beyond would then be identified as suitable for conception of a girl. The couple should avoid conception during cycles 4, 6, 8, 10 and beyond because those cycles may result in a boy conception.

This hypothesis has not been proven or backed by any scientific body. Also, no large scale clinical trials have been performed. We do not know the exact nature of the compounds involved but we have observed that the difference is strikingly clear and we have guided many couples successfully. The success rate appears to be approximately 94%.